3-Methyl-4-(5-morpholin-4-ylmethyl-furan-2-yl)-benzoic acid methyl ester → 3-Methyl-4-(5-morpholin-4-ylmethyl-furan-2-yl)-benzoic acid

HRID 606593Notes

Reaction equation

HRID 606593 reaction equation
C[O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][C:12]([CH2:15][N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)=[CH:13][CH:14]=2)=[C:6]([CH3:22])[CH:5]=1>Cl>[CH3:22][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[C:10]1[O:11][C:12]([CH2:15][N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[CH:13][CH:14]=1)[C:3]([OH:23])=[O:2]

Participants

3

Reactant 1

HCID 670475453-Methyl-4-(5-morpholin-4-ylmethyl-furan-2-yl)-benzoic acid methyl ester

Product 1

HCID 582569343-Methyl-4-(5-morpholin-4-ylmethyl-furan-2-yl)-benzoic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

This ester (0.51 mmol) was heated to 70° C. in 18% HCl for 2 h at which point HPLC showed all the starting material to have been hydrolysed. The reaction was cooled and the product that precipitated out of solution was collected by filtration as a white solid. With no further purification this was coupled using the standard procedure.

Workup

  1. temperatureThe reaction was cooled
  2. customthe product that precipitated out of solution
  3. filtrationwas collected by filtration as a white solid
  4. customWith no further purification

Sources & evidence

ORD record
ord-093a747c0f784aba8d7f321cd7a9fc6e
Source dataset
uspto-grants-2011_03
Patent number
US07915300B2

Reaction notes

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