反应详情

温度

90 °C

A mixture of 7-bromo-4-methoxy-6-azaindole (1.160 g, 5.11 mmol) and 2-(tri-n-butylstannyl)pyrazine (2.07 g, 5.62 mmol) in 25 mL of dry DMF was degassed with a stream of Ar bubbles for 10 min. To this solution was added tetrakis(triphenylphosphine)palladium (0.590 g, 0.511 mmol) and CuI (0.097 g, 0.511 mmol) and the mixture was heated in a sealed tube at 90° C. for 4 h. The cooled mixture was filtered through methanesulfonic acid SCX cartridges (7×3 g) with MeOH, to remove triphenylphosphine oxide. The filtrate was evaporated and the residue triturated with MeOH to give the title compound (0.612 g, 53%) as a light yellow solid:

1. customwas degassed with a stream of Ar bubbles for 10 min
2. filtrationThe cooled mixture was filtered through methanesulfonic acid SCX cartridges (7×3 g) with MeOH
3. customto remove triphenylphosphine oxide
4. customThe filtrate was evaporated
5. customthe residue triturated with MeOH