反应详情

Prepare essentially as described in PREPARATION 17 using a 1 M solution of tetrabutylammonium fluoride in tetrahydrofuran (4.2 mL, 4.2 mmol), 3,5-dibromopyridine (1.00 g, 4.2 mmol), 3-trimethylsilanylethynylbenzonitrile (0.84 g, 4.2 mmol), (prepared as described in PREPARATION 5), bis(triphenylphosphine)palladium (II) dichloride (0.06 g, 0.08 mmol) and copper (I) iodide (0.03 g, 0.17 mmol) to give the title compound (0.45 g, 39%).

1. customPrepare essentially