Hydrochloric Acid → 3-Bromo-5-(4-fluorophenylethynyl)-pyridine hydrochloride

HRID 606876Notes

Reaction equation

HRID 606876 reaction equation
[ClH:1].[Br:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH:8]=1>C(OCC)C>[ClH:1].[Br:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 670476153-Bromo-5-(4-fluorophenylethynyl)-pyridine

Product 1

HCID 670477633-Bromo-5-(4-fluorophenylethynyl)-pyridine hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

Add 1 M hydrogen chloride in diethyl ether (1.1 eq) to 3-bromo-5-(4-fluorophenylethynyl)-pyridine, from PREPARATION 24, in diethyl ether and stir for 2 h. Filter and dry the collected solid under high vacuum to give the title compound.

Workup

  1. customfrom PREPARATION 24
  2. filtrationFilter
  3. customdry the collected solid under high vacuum

Sources & evidence

ORD record
ord-1a0de6886ecf4be6a0bcda3e56eff07e
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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