反应详情

温度

60 °C

Add bis(triphenylphosphine)palladium (II) dichloride (70 mg, 0.10 mmol), copper (I) iodide (38 mg, 0.20 mmol), and 3-ethynyl-5-methoxypyridine, (prepared as described in PREPARATION 10), (350 mg, 2.6 mmol) to a solution of 2-fluoro-5-iodobenzamide, (prepared as described in PREPARATION 44), (0.54 g, 2.0 mmol) in triethylamine (3.1 mL, 30.3 mmol) and heat at 60° C. for 18 h. Cool to room temperature and concentrate. Purify by silica gel chromatography, eluting with 100:0 to 0:100 dichloromethane:ethyl acetate, to give the title compound as a white solid (480 mg, 68%).

1. temperatureCool to room temperature
2. concentrationconcentrate
3. customPurify by silica gel chromatography
4. washeluting with 100:0 to 0:100 dichloromethane