Hydrochloric Acid → HCID 67047742, compound

HRID 606934Notes

Reaction equation

HRID 606934 reaction equation
[ClH:1].[CH3:2][O:3][C:4](=[O:19])[C:5]1[CH:10]=[C:9]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:8]=[N:7][CH:6]=1>C(OCC)C>[ClH:1].[CH3:2][O:3][C:4](=[O:19])[C:5]1[CH:10]=[C:9]([C:11]#[C:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:8]=[N:7][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67047667HCID 67047667, compound

Product 1

HCID 67047742HCID 67047742, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

Add 1 M hydrogen chloride in diethyl ether (0.61 mL, 1.1 eq) to a solution of 5-phenylethynyl-nicotinic acid methyl ester, (prepared as described in EXAMPLE 173), (0.15 g, 0.56 mmol) in diethyl ether and stir at room temperature for 2 h. Isolate the precipitated solid by filtration to give the title compound (0.16 g, 93%).

Workup

  1. customIsolate the precipitated solid
  2. filtrationby filtration

Sources & evidence

ORD record
ord-3aa148525f06485ab93048d342839986
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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