Ethyl Acetate → HCID 67065966、化合物

HRID 607030ノート

反応式

HRID 607030 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[F:10].[CH3:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1B(O)O.C(=O)([O-])[O-].[Na+].[Na+].CCOC(C)=O>O.CCO.C1(C)C=CC=CC=1.[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CCCCCC>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[CH3:11])=[C:3]([F:10])[CH:4]=1

参加物

8

反応物 4

HCID 8857Ethyl AcetateHCID 10340Sodium CarbonateHCID 27332672-Methylphenyl boronic acidHCID 37184441-Bromo-2-fluoro-4-methoxybenzene

生成物 1

HCID 67065966HCID 67065966、化合物

試薬・触媒・溶媒 3

HCID 11979704Tetrakis(triphenylphosphine)palladium触媒HCID 8058Hexane溶媒HCID 86587398Ethanol toluene water溶媒

実験手順

A mixture of 4-bromo-3-fluoroanisole, 2-methylphenyl boronic acid, tetrakis(triphenylphosphine) palladium (5% mol) and sodium carbonate (0.23 g, 2.1 mmol) in 20 ml of water/EtOH/toluene (1:2:4) was heated to reflux for 5 h. TLC (EtOAc:hexane/2:98) showed that the reaction was over. The solvents was removed. Water (10 ml) was added. The organic was extracted with methylene chloride (3×50 ml). The combined methylene chloride layers were washed with brine, and dried over sodium sulfate. The title compound was obtained after purification with preparative TLC using 2% EtOAc in hexane as the eluant.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 5 h
  3. customThe solvents was removed
  4. additionWater (10 ml) was added
  5. extractionThe organic was extracted with methylene chloride (3×50 ml)
  6. washThe combined methylene chloride layers were washed with brine
  7. dry with materialdried over sodium sulfate

出典と根拠

ORDレコード
ord-6ced93f0142d4c5ba7895abbba116e66
出典データセット
uspto-grants-2011_03
特許番号
US07915271B2

反応ノート

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