Potassium Carbonate → 1-Chloro-4-[(4-methoxybenzyl)oxy]-2-nitrobenzene

HRID 607159Notes

Reaction equation

HRID 607159 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].Cl[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>[I-].C([N+](CCCC)(CCCC)CCCC)CCC.CN(C)C=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 691274-Chloro-3-nitrophenolHCID 699934-Methyloxybenzyl chloride

Product 1

HCID 106614161-Chloro-4-[(4-methoxybenzyl)oxy]-2-nitrobenzeneYield 96%

Reagents, catalysts & solvents 2

HCID 67553Tetrabutylammonium IodideCatalystHCID 6228DimethylformamideSolvent

Procedure

A solution of 4-chloro-3-nitro-phenol (0.5 g, 2.88 mmol), 1-chloromethyl-4-methoxy-benzene (0.496 g, 3.17 mmol), potassium carbonate (1.19 g, 8.64 mmol) and tetrabutylammonium iodide (0.005 g, 0.0135 mmol) in N,N-dimethylformamide (5 ml) was stirred at room temperature for 16 hours. Afterwards ice water (10 mL) was added to the solution and the resultant solid was collected by filtration and dried in a vacuum oven to provide the title compound (0.812 g, 96%).

Workup

  1. filtrationthe resultant solid was collected by filtration
  2. customdried in a vacuum oven

Sources & evidence

ORD record
ord-c9b95eb2cd264ada806f93a114744989
Source dataset
uspto-grants-2011_03
Patent number
US07915411B2

Reaction notes

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