Hydrazine hydrate (1:1) → Methyl 4-(3-hydrazino-1,2,4-triazin-6-yl)benzoate

HRID 607594ノート

反応式

HRID 607594 の反応式
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)=[CH:6][N:7]=1.O.[NH2:19][NH2:20]>O1CCCC1>[NH:19]([C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)=[CH:6][N:7]=1)[NH2:20]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 59216349Methyl 4-(3-chloro-1,2,4-triazin-6-yl)benzoate

生成物 1

HCID 59216328Methyl 4-(3-hydrazino-1,2,4-triazin-6-yl)benzoate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of methyl 4-(3-chloro-1,2,4-triazin-6-yl)benzoate (1.1 g, 0.0044 mol) in tetrahydrofuran (30 mL) was added hydrazine hydrate (1.1 mL, 0.022 mol) at RT with stirring. The mixture was stirred at RT for 1 h, and concentrated under reduced pressure to give the desired product (quantitatively). Analytical LCMS: (M+H)+=245.9.

後処理

  1. stirringThe mixture was stirred at RT for 1 h
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-530244efeaf444839a1908033a1c933e
出典データセット
uspto-grants-2011_03
特許番号
US07915408B2

反応ノート

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