反应详情

A solution of 5-bromo-2-methylpyridine (10 g, 58.13 mmol) and meta-chloroperbenzoic acid (mCPBA, 30 g, 174.39 mmol) in CHCl3 (160 mL) was heated at 60° C. for 16 h. The mixture was cooled to rt and neutralized with satd. NaHCO3. The resulting mixture was extracted with DCM. The organic layers were combined and washed with brine and dried (MgSO4). The solvent was removed in vacuo. The crude was purified by silica gel chromatography (EtOAc/hexanes) to obtain the title compound.

1. extractionThe resulting mixture was extracted with DCM
2. washwashed with brine
3. dry with materialdried (MgSO4)
4. customThe solvent was removed in vacuo
5. customThe crude was purified by silica gel chromatography (EtOAc/hexanes)