反应详情

温度

60 °C

N-cycloheptyl-5-bromopentanamide (4.15 g, 15 mmole) in solution in dimethylformamide (20 ml) is added dropwise to a hot solution (60° C.) of N-benzylethanolamine (2.27 g, 2.13 ml, 15 mmole) in dimethylformamide (25 ml) in the presence of potassium carbonate (4.15 g, 3 mmole). The reaction mixture is agitated for 2 hours at 60° C. then the solvent is evaporated under reduced pressure. The residue is taken up in dichloromethane (50 ml) and washed with water (3×30 ml). The organic phase is collected, dried over magnesium sulfate; the solvent is evaporated under reduced pressure. The product obtained is purified by flash chromatography over silica gel in a mixture of dichloromethane/methanol (90/10) to give 3.04 g (50%) of the expected compound in the form of an oil.

1. customthe solvent is evaporated under reduced pressure
2. washwashed with water (3×30 ml)
3. customThe organic phase is collected
4. dry with materialdried over magnesium sulfate
5. customthe solvent is evaporated under reduced pressure
6. customThe product obtained
7. customis purified by flash chromatography over silica gel in a mixture of dichloromethane/methanol (90/10)