Hydrochloric Acid → N,N-dimethyl-[5-(2-benzoylbenzoyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611118Notes

Reaction equation

HRID 611118 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:29])[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:21](=[O:28])[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3].[ClH:30]>CO.C(OCC)(=O)C>[ClH:30].[CH3:3][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:29])[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:21](=[O:28])[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19599910N,N-dimethyl-[5-(2-benzoylbenzoyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine

Product 1

HCID 19599909N,N-dimethyl-[5-(2-benzoylbenzoyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[5-(2-benzoylbenzoyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.155 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. After this mixture was concentrated, diethyl ether was added; the resulting solid was filtered and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationAfter this mixture was concentrated
  2. additiondiethyl ether was added
  3. filtrationthe resulting solid was filtered
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-6e950a86e2b84a129d0470a83b9ee328
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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