Hydrochloric Acid → HCID 19600238, compound

HRID 611150Notes

Reaction equation

HRID 611150 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:27][C:8]2[CH2:9][N:10]([C:13](=[O:26])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:28]>CO.C(OCC)(=O)C>[ClH:28].[CH3:1][N:2]([CH2:4][C:5]1[O:27][C:8]2[CH2:9][N:10]([C:13](=[O:26])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600003HCID 19600003, compound

Product 1

HCID 19600238HCID 19600238, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

1-(2-Dimethylaminomethyl-5,7-dihydro-4H-furo[2,3-c]pyridin-6-yl)-6-(4-fluorophenyl)hexan-1-one 0.098 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. After this mixture was concentrated, the resulting solid was washed with diethyl ether to yield the desired product.

Workup

  1. concentrationAfter this mixture was concentrated
  2. washthe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-6068050c85114646850f3e70977a81df
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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