Hydrochloric Acid → HCID 19600204, compound

HRID 611246Notes

Reaction equation

HRID 611246 reaction equation
[O:1]1[CH2:5][CH2:4][N:3]=[C:2]1[C:6]1[O:27][C:9]2[CH2:10][N:11]([C:14](=[O:26])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:12][CH2:13][C:8]=2[CH:7]=1.[ClH:28]>C(OCC)C.CO>[ClH:28].[O:1]1[CH2:5][CH2:4][N:3]=[C:2]1[C:6]1[O:27][C:9]2[CH2:10][N:11]([C:14](=[O:26])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:12][CH2:13][C:8]=2[CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600009HCID 19600009, compound

Product 1

HCID 19600204HCID 19600204, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of 0.148 g of 1-[2-(2-oxazolin-2-yl)-5,7-dihydro-4H-furo[2,3-c]pyridin-6-yl]-6-phenylhexan-1-one in 10 ml of diethyl ether, 0.5 ml of about 10% hydrogen chloride in methanol was added, followed by stirring for 10 minutes, after which the solvent was distilled off under reduced pressure. The resulting crude product was crystallized from diethyl ether to yield the desired product.

Workup

  1. distillationafter which the solvent was distilled off under reduced pressure
  2. customThe resulting crude product was crystallized from diethyl ether

Sources & evidence

ORD record
ord-332d630ae3d04deb8a4e1a025f9d35e2
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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