Hydrochloric Acid → N,N-dimethyl-[6-[4-(4-fluorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611274Notes

Reaction equation

HRID 611274 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:30][C:8]2[CH2:9][N:10]([C:13](=[O:29])[C:14]3[CH:19]=[CH:18][C:17]([C:20](=[O:28])[C:21]4[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:31]>CO.C(OCC)(=O)C>[ClH:31].[CH3:3][N:2]([CH2:4][C:5]1[O:30][C:8]2[CH2:9][N:10]([C:13](=[O:29])[C:14]3[CH:15]=[CH:16][C:17]([C:20](=[O:28])[C:21]4[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=4)=[CH:18][CH:19]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600005HCID 19600005, compound

Product 1

HCID 19600195N,N-dimethyl-[6-[4-(4-fluorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[6-[4-(4-fluorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.114 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This was concentrated; the resulting solid was washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis was concentrated
  2. washthe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-497c9bca690147a78311941036eeb1cf
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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