Hydrochloric Acid → HCID 19600244, compound

HRID 611276Notes

Reaction equation

HRID 611276 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:30])[C:15]3[CH:20]=[CH:19][C:18]([C:21](=[O:29])[C:22]4[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=4)=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3].[ClH:31]>CO.C(OCC)(=O)C>[ClH:31].[CH3:3][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:30])[C:15]3[CH:20]=[CH:19][C:18]([C:21](=[O:29])[C:22]4[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=4)=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19599911HCID 19599911, compound

Product 1

HCID 19600244HCID 19600244, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[5-[4-(4-fluorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.116 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was then concentrated; the resulting solid was washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was then concentrated
  2. washthe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-d1fa804895214443b55c2e6a405dd632
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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