Hydrochloric Acid → HCID 19600224, compound

HRID 611283Notes

Reaction equation

HRID 611283 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:30])[C:15]3[CH:20]=[CH:19][C:18]([C:21](=[O:29])[C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=4)=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3].Cl>CO.C(OCC)(=O)C>[ClH:28].[CH3:3][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:30])[C:15]3[CH:16]=[CH:17][C:18]([C:21](=[O:29])[C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=4)=[CH:19][CH:20]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600125HCID 19600125, compound

Product 1

HCID 19600224HCID 19600224, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[5-[4-(3-chlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.160 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This was concentrated; the resulting solid was washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis was concentrated
  2. washthe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-6a19e3bff49f406a821a95f2d354da77
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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