Hydrochloric Acid → N,N-dimethyl-[6-[4-(2,4-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611285Notes

Reaction equation

HRID 611285 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:31][C:8]2[CH2:9][N:10]([C:13](=[O:30])[C:14]3[CH:19]=[CH:18][C:17]([C:20](=[O:29])[C:21]4[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=4[Cl:28])=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].Cl>CO.C(OCC)(=O)C>[ClH:27].[CH3:3][N:2]([CH2:4][C:5]1[O:31][C:8]2[CH2:9][N:10]([C:13](=[O:30])[C:14]3[CH:19]=[CH:18][C:17]([C:20](=[O:29])[C:21]4[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=4[Cl:28])=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600173HCID 19600173, compound

Product 1

HCID 19600232N,N-dimethyl-[6-[4-(2,4-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[6-[4-(2,4-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.135 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This was concentrated; the resulting solid was washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis was concentrated
  2. washthe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-ecb7ebd6e2af410fb01a981692050bb8
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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