Dimethylamine → HCID 19599992, compound

HRID 611288Notes

Reaction equation

HRID 611288 reaction equation
Cl.[O:2]1[C:6]2[CH2:7][NH:8][CH2:9][CH2:10][C:5]=2[CH:4]=[CH:3]1.[Cl:11][C:12]1[CH:13]=[C:14]([CH:26]=[CH:27][C:28]=1[Cl:29])[C:15]([C:17]1[CH:25]=[CH:24][C:20]([C:21](O)=[O:22])=[CH:19][CH:18]=1)=[O:16].[CH2:30]([N:32]([CH2:35]C)[CH2:33]C)C.C(P(=O)(OCC)OCC)#N.CNC.C=O>ClCCl>[CH3:30][N:32]([CH2:35][C:3]1[O:2][C:6]2[CH2:7][N:8]([C:21](=[O:22])[C:20]3[CH:24]=[CH:25][C:17]([C:15](=[O:16])[C:14]4[CH:26]=[CH:27][C:28]([Cl:29])=[C:12]([Cl:11])[CH:13]=4)=[CH:18][CH:19]=3)[CH2:9][CH2:10][C:5]=2[CH:4]=1)[CH3:33]

Participants

8

Reactant 6

HCID 674DimethylamineHCID 712FormaldehydeHCID 8471TriethylamineHCID 76257Diethyl cyanophosphonateHCID 195999074,5,6,7-Tetrahydrofuro[2,3-c]pyridine hydrochlorideHCID 196002214-(3,4-Dichlorobenzoyl)benzoic acid

Product 1

HCID 19599992HCID 19599992, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 0.160 g (1.000 mmol) of 4,5,6,7-tetrahydrofuro[2,3-c]pyridine hydrochloride, 0.325 g (1.1 mmol) of 4-(3,4-dichlorobenzoyl)benzoic acid and 0.55 ml (4.0 mmol) of triethylamine in 30 ml of dichloromethane, 0.24 g (1.5 mmol) of diethyl cyanophosphonate was added dropwise under ice-cooling, followed by overnight stirring at room temperature. After the solvent was distilled off, water was added, followed by 2 extractions with ethyl acetate. The combined organic layer was washed with water and dried over anhydrous sodium sulfate; the solvent was distilled off under reduced pressure. The resulting crude product was dissolved in 10 ml of acetic acid; 0.135 ml (1.50 mmol) of 50% aqueous dimethylamine and 0.122 ml (1.50 mmol) of 37% aqueous solution of formaldehyde were added, followed by stirring at 100° C. for 100 minutes. After the solvent was distilled off under reduced pressure, the residual solution was alkalified with 5% aqueous sodium hydrogen carbonate and extracted with ethyl acetate 2 times. The combined organic layer was washed with water and dried over anhydrous sodium sulfate; the solvent was distilled off under reduced pressure. The resulting crude product was purified by silica gel column chromatography (ethyl acetate/methanol=5/1). The resulting purified product was washed with diethyl ether to yield the desired product.

Workup

  1. temperaturecooling
  2. distillationAfter the solvent was distilled off
  3. additionwater was added
  4. extractionfollowed by 2 extractions with ethyl acetate
  5. washThe combined organic layer was washed with water
  6. dry with materialdried over anhydrous sodium sulfate
  7. distillationthe solvent was distilled off under reduced pressure
  8. dissolutionThe resulting crude product was dissolved in 10 ml of acetic acid
  9. stirringby stirring at 100° C. for 100 minutes
  10. distillationAfter the solvent was distilled off under reduced pressure
  11. extractionextracted with ethyl acetate 2 times
  12. washThe combined organic layer was washed with water
  13. dry with materialdried over anhydrous sodium sulfate
  14. distillationthe solvent was distilled off under reduced pressure
  15. customThe resulting crude product was purified by silica gel column chromatography (ethyl acetate/methanol=5/1)
  16. customThe resulting purified product
  17. washwas washed with diethyl ether

Sources & evidence

ORD record
ord-7e8c8238d538498d8e58f7fcb5195077
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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