Hydrochloric Acid → N,N-dimethyl-[5-[4-(3,4-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611291Notes

Reaction equation

HRID 611291 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:31])[C:15]3[CH:20]=[CH:19][C:18]([C:21](=[O:30])[C:22]4[CH:27]=[CH:26][C:25]([Cl:28])=[C:24]([Cl:29])[CH:23]=4)=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3].Cl>CO.C(OCC)(=O)C>[ClH:28].[CH3:3][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:31])[C:15]3[CH:16]=[CH:17][C:18]([C:21](=[O:30])[C:22]4[CH:27]=[CH:26][C:25]([Cl:28])=[C:24]([Cl:29])[CH:23]=4)=[CH:19][CH:20]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600011N,N-dimethyl-[5-[4-(3,4-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine

Product 1

HCID 19600010N,N-dimethyl-[5-[4-(3,4-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[5-[4-(3,4-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.139 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This was concentrated, and recrystallized from methanol-diethyl ether to yield the desired product.

Workup

  1. concentrationThis was concentrated
  2. customrecrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-e6859efa804b44fea7bef57ac6589a04
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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