Hydrochloric Acid → N,N-dimethyl-[6-[4-(3,5-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611293Notes

Reaction equation

HRID 611293 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:31][C:8]2[CH2:9][N:10]([C:13](=[O:30])[C:14]3[CH:19]=[CH:18][C:17]([C:20](=[O:29])[C:21]4[CH:26]=[C:25]([Cl:27])[CH:24]=[C:23]([Cl:28])[CH:22]=4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].Cl>CO.C(OCC)(=O)C>[ClH:27].[CH3:3][N:2]([CH2:4][C:5]1[O:31][C:8]2[CH2:9][N:10]([C:13](=[O:30])[C:14]3[CH:19]=[CH:18][C:17]([C:20](=[O:29])[C:21]4[CH:22]=[C:23]([Cl:28])[CH:24]=[C:25]([Cl:27])[CH:26]=4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19599973N,N-dimethyl-[6-[4-(3,5-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine

Product 1

HCID 19599972N,N-dimethyl-[6-[4-(3,5-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[6-[4-(3,5-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.140 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was then concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was then concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-f99effe83a6c4e9a88db207f4be63e68
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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