Hydrochloric Acid → N,N-dimethyl-[5-[4-(2-thenoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611304Notes

Reaction equation

HRID 611304 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:28])[C:15]3[CH:20]=[CH:19][C:18]([C:21](=[O:27])[C:22]4[S:26][CH:25]=[CH:24][CH:23]=4)=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3].[ClH:29]>CO.C(OCC)(=O)C>[ClH:29].[CH3:3][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:28])[C:15]3[CH:20]=[CH:19][C:18]([C:21](=[O:27])[C:22]4[S:26][CH:25]=[CH:24][CH:23]=4)=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600065HCID 19600065, compound

Product 1

HCID 19600156N,N-dimethyl-[5-[4-(2-thenoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[5-[4-(2-thenoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.184 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was then concentrated, and recrystallized from methanol-diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was then concentrated
  2. customrecrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-b0d98f5549ef4c4f86cea6711b94f778
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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