Hydrochloric Acid → HCID 19600186, compound

HRID 611309Notes

Reaction equation

HRID 611309 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:28])[C:15]3[CH:20]=[CH:19][C:18]([C:21]([C:23]4[O:24][CH:25]=[CH:26][CH:27]=4)=[O:22])=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3].[ClH:29]>CO.C(OCC)(=O)C>[ClH:29].[CH3:3][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:28])[C:15]3[CH:20]=[CH:19][C:18]([C:21]([C:23]4[O:24][CH:25]=[CH:26][CH:27]=4)=[O:22])=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600077HCID 19600077, compound

Product 1

HCID 19600186HCID 19600186, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[5-[4-(2-furoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.148 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was then concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was then concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-936f979ca84e49d0bd405674d42872d6
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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