Hydrochloric Acid → HCID 86754931, compound

HRID 611326Notes

Reaction equation

HRID 611326 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:37][C:8]2[CH2:9][N:10]([C:13]([C:15]3[CH:36]=[CH:35][C:18](/[CH:19]=[CH:20]\[C:21]4[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[C:23]([C:31]([F:34])([F:33])[F:32])[CH:22]=4)=[CH:17][CH:16]=3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:38]>CO.C(OCC)(=O)C>[ClH:38].[CH3:1][N:2]([CH2:4][C:5]1[O:37][C:8]2[CH2:9][N:10]([C:13]([C:15]3[CH:16]=[CH:17][C:18](/[CH:19]=[CH:20]\[C:21]4[CH:22]=[C:23]([C:31]([F:32])([F:33])[F:34])[CH:24]=[C:25]([C:27]([F:29])([F:30])[F:28])[CH:26]=4)=[CH:35][CH:36]=3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86754929HCID 86754929, compound

Product 1

HCID 86754931HCID 86754931, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

(Z)-N,N-Dimethyl-[6-[3,5-bis(trifluoromethyl)stilbene-4'-carbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.694 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with hexane to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washwashed with hexane

Sources & evidence

ORD record
ord-5e378a9701404916999e25652e0e2395
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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