Hydrochloric Acid → HCID 86754933, compound

HRID 611328Notes

Reaction equation

HRID 611328 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14]([C:16]3[CH:37]=[CH:36][C:19](/[CH:20]=[CH:21]\[C:22]4[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[C:24]([C:32]([F:35])([F:34])[F:33])[CH:23]=4)=[CH:18][CH:17]=3)=[O:15])[CH2:8][C:7]=2[CH:6]=1)[CH3:3].[ClH:38]>CO.C(OCC)(=O)C>[ClH:38].[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14]([C:16]3[CH:37]=[CH:36][C:19](/[CH:20]=[CH:21]\[C:22]4[CH:27]=[C:26]([C:28]([F:29])([F:30])[F:31])[CH:25]=[C:24]([C:32]([F:34])([F:33])[F:35])[CH:23]=4)=[CH:18][CH:17]=3)=[O:15])[CH2:8][C:7]=2[CH:6]=1)[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86754932HCID 86754932, compound

Product 1

HCID 86754933HCID 86754933, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

(Z)-N,N-Dimethyl-[5-[3,5-bis(trifluoromethyl)stilbene-4'-carbonyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.300 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with hexane to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washwashed with hexane

Sources & evidence

ORD record
ord-970bf098a51a403e834e4a18fc221784
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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