Hydrochloric Acid → HCID 67585989, compound

HRID 611330Notes

Reaction equation

HRID 611330 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:28][C:8]2[CH2:9][N:10]([C:13]([C:15]3[S:16][C:17](/[CH:20]=[CH:21]\[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)=[CH:18][CH:19]=3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:29]>CO.C(OCC)(=O)C>[ClH:29].[CH3:1][N:2]([CH2:4][C:5]1[O:28][C:8]2[CH2:9][N:10]([C:13]([C:15]3[S:16][C:17](/[CH:20]=[CH:21]\[C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)=[CH:18][CH:19]=3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67585886HCID 67585886, compound

Product 1

HCID 67585989HCID 67585989, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

(Z)-N,N-Dimethyl-[6-[5-(2-phenylethenyl)thiophene-2-carbonyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.157 g was dissolved in methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated, and recrystallized from methanol-diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. customrecrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-f7383f3792a04950884b596dfacfc663
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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