Hydrochloric Acid → HCID 67585058, compound

HRID 611332Notes

Reaction equation

HRID 611332 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14]([C:16]3[S:17][C:18](/[CH:21]=[CH:22]\[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:19][CH:20]=3)=[O:15])[CH2:8][C:7]=2[CH:6]=1)[CH3:3].[ClH:29]>CO.C(OCC)(=O)C>[ClH:29].[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14]([C:16]3[S:17][C:18](/[CH:21]=[CH:22]\[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:19][CH:20]=3)=[O:15])[CH2:8][C:7]=2[CH:6]=1)[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67584811HCID 67584811, compound

Product 1

HCID 67585058HCID 67585058, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

(Z)-N,N-Dimethyl-[5-[5-(2-phenylethenyl)thiophene-2-carbonyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.095 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated, and recrystallized from methanol-diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. customrecrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-a0fe04c9706a4822be3a350c02ce7a65
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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