Hydrochloric Acid → HCID 19600193, compound

HRID 611334Notes

Reaction equation

HRID 611334 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:28][C:8]2[CH2:9][N:10]([C:13]([C:15]3[S:16][C:17](/[CH:20]=[CH:21]/[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)=[CH:18][CH:19]=3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:29]>CO.C(OCC)(=O)C>[ClH:29].[CH3:1][N:2]([CH2:4][C:5]1[O:28][C:8]2[CH2:9][N:10]([C:13]([C:15]3[S:16][C:17](/[CH:20]=[CH:21]/[C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)=[CH:18][CH:19]=3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600151HCID 19600151, compound

Product 1

HCID 19600193HCID 19600193, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

(E)-N,N-Dimethyl-[6-[5-(2-phenylethenyl)thiophene-2-carbonyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.165 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-a44ba991d5794953b20fee79d5cfcf13
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

Loading…