Hydrochloric Acid → HCID 19600183, compound

HRID 611336Notes

Reaction equation

HRID 611336 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14]([C:16]3[S:17][C:18](/[CH:21]=[CH:22]/[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:19][CH:20]=3)=[O:15])[CH2:8][C:7]=2[CH:6]=1)[CH3:3].[ClH:29]>CO.C(OCC)(=O)C>[ClH:29].[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14]([C:16]3[S:17][C:18](/[CH:21]=[CH:22]/[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:19][CH:20]=3)=[O:15])[CH2:8][C:7]=2[CH:6]=1)[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600134HCID 19600134, compound

Product 1

HCID 19600183HCID 19600183, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

(E)-N,N-Dimethyl-[5-[5-(2-phenylethenyl)thiophene-2-carbonyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.124 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-e2dd758b4ab747fbb0335cc5a2955a63
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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