Hydrochloric Acid → N,N-dimethyl-(6-(9-fluorenone-2-carbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611338Notes

Reaction equation

HRID 611338 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:29][C:8]2[CH2:9][N:10]([C:13]([C:15]3[CH:27]=[CH:26][C:25]4[C:24]5[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=5)[C:18](=[O:28])[C:17]=4[CH:16]=3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:30]>CO.C(OCC)(=O)C>[ClH:30].[CH3:3][N:2]([CH2:4][C:5]1[O:29][C:8]2[CH2:9][N:10]([C:13]([C:15]3[CH:27]=[CH:26][C:25]4[C:24]5[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=5)[C:18](=[O:28])[C:17]=4[CH:16]=3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19599904N,N-Dimethyl-[6-(9-fluorenone-2-carbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine

Product 1

HCID 19599903N,N-dimethyl-(6-(9-fluorenone-2-carbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[6-(9-fluorenone-2-carbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.188 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated; the resulting solid was washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washthe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-ec211987803b4f97b87ace0e800d337b
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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