Hydrochloric Acid → N,N-dimethyl-[6-(2-fluorenecarbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611342Notes

Reaction equation

HRID 611342 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:28][C:8]2[CH2:9][N:10]([C:13]([C:15]3[CH:27]=[CH:26][C:25]4[C:24]5[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=5)[CH2:18][C:17]=4[CH:16]=3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:29]>CO.C(OCC)(=O)C>[ClH:29].[CH3:3][N:2]([CH2:4][C:5]1[O:28][C:8]2[CH2:9][N:10]([C:13]([C:15]3[CH:27]=[CH:26][C:25]4[C:24]5[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=5)[CH2:18][C:17]=4[CH:16]=3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600025N,N-dimethyl-[6-(2-fluorenecarbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine

Product 1

HCID 19600263N,N-dimethyl-[6-(2-fluorenecarbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[6-(2-fluorenecarbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.432 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated, and recrystallized from methanol-diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. customrecrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-19999cbf77974a53be7e1a35bb2fa56e
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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