Hydrochloric Acid → N,N-dimethyl-[6-(1-benzoylpiperidine-4-carbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611348Notes

Reaction equation

HRID 611348 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:29][C:8]2[CH2:9][N:10]([C:13]([CH:15]3[CH2:20][CH2:19][N:18]([C:21](=[O:28])[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:17][CH2:16]3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:30]>CO.C(OCC)(=O)C>[ClH:30].[CH3:3][N:2]([CH2:4][C:5]1[O:29][C:8]2[CH2:9][N:10]([C:13]([CH:15]3[CH2:20][CH2:19][N:18]([C:21](=[O:28])[C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:17][CH2:16]3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600056N,N-Dimethyl-[6-(1-benzoylpiperidine-4-carbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine

Product 1

HCID 19600128N,N-dimethyl-[6-(1-benzoylpiperidine-4-carbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[6-(1-benzoylpiperidine-4-carbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.330 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-f0b87e2063114644a32529b5bcd984f8
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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