Hydrochloric Acid → HCID 19600162, compound

HRID 611365Notes

Reaction equation

HRID 611365 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:30][C:8]2[CH2:9][N:10]([C:13](=[O:29])[C:14]3[CH:19]=[CH:18][C:17]([CH:20]4[CH2:22][CH:21]4[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:31]>CO.C(OCC)(=O)C>[ClH:31].[CH3:3][N:2]([CH2:4][C:5]1[O:30][C:8]2[CH2:9][N:10]([C:13](=[O:29])[C:14]3[CH:19]=[CH:18][C:17]([CH:20]4[CH2:22][CH:21]4[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600150HCID 19600150, compound

Product 1

HCID 19600162HCID 19600162, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[6-[4-(2-phenylcyclopropyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.203 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-8055cf58c02a4dc684dcba685b606f7f
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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