Hydrochloric Acid → HCID 19600259, compound

HRID 611367Notes

Reaction equation

HRID 611367 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:30])[C:15]3[CH:20]=[CH:19][C:18]([CH:21]4[CH2:23][CH:22]4[C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3].[ClH:31]>CO.C(OCC)(=O)C>[ClH:31].[CH3:3][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:30])[C:15]3[CH:16]=[CH:17][C:18]([CH:21]4[CH2:23][CH:22]4[C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)=[CH:19][CH:20]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19599999HCID 19599999, compound

Product 1

HCID 19600259HCID 19600259, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[5-[4-(2-phenylcyclopropyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.180 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-a3c7bc681d174ae3b88af8a72cbceaa3
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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