Hydrochloric Acid → 6-[4-(1-Phenylethenyl)benzoyl]-2-(1-pyrrolidinylmethyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridine hydrochloride

HRID 611372Notes

Reaction equation

HRID 611372 reaction equation
[C:1]1([C:7]([C:9]2[CH:31]=[CH:30][C:12]([C:13]([N:15]3[CH2:20][CH2:19][C:18]4[CH:21]=[C:22]([CH2:24][N:25]5[CH2:29][CH2:28][CH2:27][CH2:26]5)[O:23][C:17]=4[CH2:16]3)=[O:14])=[CH:11][CH:10]=2)=[CH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:32]>CO>[ClH:32].[C:1]1([C:7]([C:9]2[CH:10]=[CH:11][C:12]([C:13]([N:15]3[CH2:20][CH2:19][C:18]4[CH:21]=[C:22]([CH2:24][N:25]5[CH2:29][CH2:28][CH2:27][CH2:26]5)[O:23][C:17]=4[CH2:16]3)=[O:14])=[CH:30][CH:31]=2)=[CH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 195999626-[4-(1-Phenylethenyl)benzoyl]-2-(1-pyrrolidinylmethyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridine

Product 1

HCID 196001166-[4-(1-Phenylethenyl)benzoyl]-2-(1-pyrrolidinylmethyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

6-[4-(1-Phenylethenyl)benzoyl]-2-(1-pyrrolidinylmethyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridine 0.688 g was dissolved in 2 ml of methanol and hydrogen chloride in methanol was added in excess, followed by stirring. This mixture was concentrated to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated

Sources & evidence

ORD record
ord-2b203cbe85fe4e38a523d5387ae45cfe
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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