Hydrochloric Acid → HCID 19600264, compound

HRID 611380Notes

Reaction equation

HRID 611380 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:30][C:8]2[CH2:9][N:10]([C:13](=[O:29])[C:14]3[CH:19]=[CH:18][C:17]([C:20]4([C:23]5[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=5)[CH2:22][CH2:21]4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:31]>CO.C(OCC)(=O)C>[ClH:31].[CH3:3][N:2]([CH2:4][C:5]1[O:30][C:8]2[CH2:9][N:10]([C:13](=[O:29])[C:14]3[CH:19]=[CH:18][C:17]([C:20]4([C:23]5[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=5)[CH2:21][CH2:22]4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600002HCID 19600002, compound

Product 1

HCID 19600264HCID 19600264, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[6-[4-(1-phenylcyclopropyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.183 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-e48229a4f922486baa778cfafb858b24
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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