Hydrochloric Acid → HCID 19600140, compound

HRID 611385Notes

Reaction equation

HRID 611385 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:30])[C:15]3[CH:20]=[CH:19][C:18]([C:21]4([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)[CH2:23][CH2:22]4)=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3].[ClH:31]>CO.C(OCC)(=O)C>[ClH:31].[CH3:3][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:30])[C:15]3[CH:20]=[CH:19][C:18]([C:21]4([C:24]5[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=5)[CH2:22][CH2:23]4)=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600141HCID 19600141, compound

Product 1

HCID 19600140HCID 19600140, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[5-[4-(1-phenylcyclopropyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.270 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-7bc75e0c31d54aaeb089cbb14fbd6ce5
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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