Hydrochloric Acid → HCID 19600013, compound

HRID 611387Notes

Reaction equation

HRID 611387 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:32][C:8]2[CH2:9][N:10]([C:13](=[O:31])[C:14]3[CH:19]=[CH:18][C:17]([C:20]4([C:25]5[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=5)[S:24][CH2:23][CH2:22][S:21]4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:33]>CO.C(OCC)(=O)C>[ClH:33].[CH3:3][N:2]([CH2:4][C:5]1[O:32][C:8]2[CH2:9][N:10]([C:13](=[O:31])[C:14]3[CH:19]=[CH:18][C:17]([C:20]4([C:25]5[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=5)[S:21][CH2:22][CH2:23][S:24]4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19599922HCID 19599922, compound

Product 1

HCID 19600013HCID 19600013, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[6-[4-(2-phenyl-1,3-dithiolan-2-yl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.384 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-e191612c182141cda5b332f8caf02cc8
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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