Hydrochloric Acid → HCID 19600109, compound

HRID 611392Notes

Reaction equation

HRID 611392 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:32])[C:15]3[CH:20]=[CH:19][C:18]([C:21]4([C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=5)[S:25][CH2:24][CH2:23][S:22]4)=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3].[ClH:33]>CO.C(OCC)(=O)C>[ClH:33].[CH3:3][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:32])[C:15]3[CH:16]=[CH:17][C:18]([C:21]4([C:26]5[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=5)[S:22][CH2:23][CH2:24][S:25]4)=[CH:19][CH:20]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19599953HCID 19599953, compound

Product 1

HCID 19600109HCID 19600109, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[5-[4-(2-phenyl-1,3-dithiolan-2-yl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.271 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-832dd01739d84ff6959808231e0357b7
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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