Hydrochloric Acid → HCID 19600178, compound

HRID 611394Notes

Reaction equation

HRID 611394 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:33][C:8]2[CH2:9][N:10]([C:13](=[O:32])[C:14]3[CH:19]=[CH:18][C:17]([C:20]4([C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=5)[S:25][CH2:24][CH2:23][CH2:22][S:21]4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:34]>CO.C(OCC)(=O)C>[ClH:34].[CH3:3][N:2]([CH2:4][C:5]1[O:33][C:8]2[CH2:9][N:10]([C:13](=[O:32])[C:14]3[CH:19]=[CH:18][C:17]([C:20]4([C:26]5[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=5)[S:21][CH2:22][CH2:23][CH2:24][S:25]4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600084HCID 19600084, compound

Product 1

HCID 19600178HCID 19600178, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[6-[4-(2-phenyl-1,3-dithian-2-yl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.533 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-a2186fe90f87480fb55e815a3482ee5d
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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