Hydrochloric Acid → HCID 19600207, compound

HRID 611396Notes

Reaction equation

HRID 611396 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:33])[C:15]3[CH:20]=[CH:19][C:18]([C:21]4([C:27]5[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=5)[S:26][CH2:25][CH2:24][CH2:23][S:22]4)=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3].[ClH:34]>CO.C(OCC)(=O)C>[ClH:34].[CH3:3][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:33])[C:15]3[CH:16]=[CH:17][C:18]([C:21]4([C:27]5[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=5)[S:22][CH2:23][CH2:24][CH2:25][S:26]4)=[CH:19][CH:20]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19600032HCID 19600032, compound

Product 1

HCID 19600207HCID 19600207, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N,N-Dimethyl-[5-[4-(2-phenyl-1,3-dithian-2-yl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.368 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-99600573d6154d6d91955846042db291
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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