Hydrochloric Acid → HCID 15342560, compound

HRID 611477Notes

Reaction equation

HRID 611477 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([NH:13][CH2:14][C:15]([O:17][CH3:18])=[O:16])[C:6](=[CH:11][CH:12]=1)[C:7]([O:9]C)=O.[O-:19][C:20]#[N:21].[K+]>S1(CCCC1)(=O)=O>[Cl:2][C:3]1[CH:4]=[C:5]2[C:6]([C:7](=[O:9])[NH:21][C:20](=[O:19])[N:13]2[CH2:14][C:15]([O:17][CH3:18])=[O:16])=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11378442Potassium cyanateHCID 15346298HCID 15346298, compound

Product 1

HCID 15342560HCID 15342560, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 31347SulfolaneSolvent

Procedure

Hydrogen chloride is passed into 1 g of methyl 4-chloro-N-(methoxycarbonylmethyl)anthranilate and 1.6 g of potassium cyanate in 20 ml of sulfolane at 50° C. until analysis by HPLC indicates complete conversion. The product is precipitated by addition of water, filtered off, washed with water and dried. 0.59 g (57%) of methyl 1,2,3,4-tetrahydro-7-chloro-2,4-dioxoquinazolin-1-ylacetate is obtained.

Workup

  1. customThe product is precipitated by addition of water
  2. filtrationfiltered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-ea37c61992fb4c599b247a0301cafa8a
Source dataset
uspto-grants-1999_12
Patent number
US06001831

Reaction notes

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