Hydrazine hydrate (1:1) → HCID 19597276, compound

HRID 611487Notes

Reaction equation

HRID 611487 reaction equation
Cl.C([N:9]1[C:18]2[C:13](=[CH:14][C:15]([N:23]3[CH:27]=[C:26]([CH3:28])[N:25]=[C:24]3[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[C:16]([C:19]([F:22])([F:21])[F:20])[CH:17]=2)[N:12]=[C:11](Cl)[C:10]1=[O:36])C1C=CC=CC=1.[OH2:37].[NH2:38][NH2:39]>ClCCl>[CH2:19]([O:37][N:9]1[C:18]2[C:13](=[CH:14][C:15]([N:23]3[CH:27]=[C:26]([CH3:28])[N:25]=[C:24]3[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[C:16]([C:19]([F:21])([F:22])[F:20])[CH:17]=2)[N:12]=[C:11]([NH:38][NH2:39])[C:10]1=[O:36])[C:16]1[CH:17]=[CH:18][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19597268HCID 19597268, compound

Product 1

HCID 19597276HCID 19597276, compoundYield 174.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

A mixture of 1-benzyl-3-chloro-6-(4-methyl-2-phenyl-1H-imidazol-1-yl)-7-trifluoromethylquinoxalin-2(1H)-one hydrochloride (2.0 g, 3.6 mmol) and hydrazine hydrate (0.74 ml, 15 mmol) in 40 ml of dichloromethane was stirred at 0° C. for 1 h and evaporated to dryness in vacuo. The residue was triturated with water to give 1.59 g (87%) of the title compound. M.p. 127-130° C.

Workup

  1. customevaporated to dryness in vacuo
  2. customThe residue was triturated with water

Sources & evidence

ORD record
ord-8746e2c9b02d4775990626e70a8a718d
Source dataset
uspto-grants-1999_12
Patent number
US06001832

Reaction notes

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