Acetic Acid → HCID 178467663, compound

HRID 611489Notes

Reaction equation

HRID 611489 reaction equation
C(O[P:4]([CH2:9][C:10]([NH:12][NH:13][C:14]1[C:15](=[O:41])[N:16](O)[C:17]2[C:22]([N:23]=1)=[CH:21][C:20]([N:24]1[CH:28]=[C:27]([CH3:29])[N:26]=[C:25]1[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[C:19]([C:36]([F:39])([F:38])[F:37])[CH:18]=2)=O)([O:6]CC)=[O:5])C.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:61](O)(=[O:63])[CH3:62]>>[CH2:61]([O:63][C:9](=[P:4]([OH:6])=[O:5])[C:10]1[N:23]2[C:22]3[C:17]([NH:16][C:15](=[O:41])[C:14]2=[N:13][N:12]=1)=[CH:18][C:19]([C:36]([F:39])([F:38])[F:37])=[C:20]([N:24]1[CH:28]=[C:27]([CH3:29])[N:26]=[C:25]1[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)[CH:21]=3)[CH3:62]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 11776TriphenylphosphineHCID 19597260HCID 19597260, compound

Product 1

HCID 178467663HCID 178467663, compound

Procedure

A solution of 3-[2-[(diethoxyphosphoryl)acetyl]hydrazino]-1-hydroxy-6-(4-methyl-2-phenyl-1H-imidazol-1-yl)-7-trifluoromethylquinoxalin-2(1H)-one (1.5 g, 2.5 mmol) and triphenylphosphine (1.3 g, 5 mmol) in 50 ml of glacial acetic acid was stirred overnight at 120° C.

Sources & evidence

ORD record
ord-7d1fbb6825cd4e77979673b93bd48e84
Source dataset
uspto-grants-1999_12
Patent number
US06001832

Reaction notes

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