Hydrochloric Acid → HCID 70204452, compound

HRID 611583Notes

Reaction equation

HRID 611583 reaction equation
C([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[C:13]#[CH:14])(OC(C)(C)C)=O.[CH3:15][OH:16].[ClH:17].O>C(O)C>[ClH:17].[CH3:13][C:9]1[N:8]=[C:12]2[CH:14]=[C:13]([C@H:9]3[CH2:10][CH2:11][CH2:12][NH:8]3)[O:16][C:15]2=[CH:11][CH:10]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 10262067tert-butyl (2R)-2-ethynylpyrrolidine-1-carboxylate

Product 1

HCID 70204452HCID 70204452, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from 1-Boc-2(R)-ethynylpyrrolidine according to the procedures of Example 5 above: [α]D≤ +16.5° (c 1.0, MeOH); Anal. Calcd for C12H14N2O.2.0 HCl.0.2 H2O.0.2 ethanol: C, 51.39; H, 6.19; N, 9.67. Found: C, 51.63; H, 6.49; N, 9.33.

Sources & evidence

ORD record
ord-cf18250a4d0442579d0a156b79271f9c
Source dataset
uspto-grants-1999_12
Patent number
US06001849

Reaction notes

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