Isopropyl isocyanate → HCID 19598328, compound

HRID 611764Notes

Reaction equation

HRID 611764 reaction equation
[OH:1][CH:2]([CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)[CH2:3][O:4][NH2:5].[CH:13]([N:16]=[C:17]=[O:18])([CH3:15])[CH3:14]>C(Cl)(Cl)Cl>[CH:13]([NH:16][C:17]([NH:5][O:4][CH2:3][CH:2]([OH:1])[CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)=[O:18])([CH3:15])[CH3:14]

Participants

4

Reactant 2

HCID 61277Isopropyl isocyanateHCID 187662101-(Aminooxy)-3-(piperidin-1-yl)propan-2-ol

Product 1

HCID 19598328HCID 19598328, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

O-(2-hydroxy-3-piperidino-propyl)-hydroxylamine (1,74 g, 0,01 mol) was dissolved in 25 ml abs. chloroform and under stirring, 0,98 ml (0,01 mol) isopropyl isocyanate was added. The reaction was monitored by chromatography. At the end of the reaction the solution was evaporated and the oily residue purified by column chromatography. The oil thus obtained was crystallized with methanol-ether.

Workup

  1. customAt the end of the reaction the solution
  2. customwas evaporated
  3. customthe oily residue purified by column chromatography
  4. customThe oil thus obtained
  5. customwas crystallized with methanol-ether

Sources & evidence

ORD record
ord-ee156c9509bc47a595b6e51d72ce0b77
Source dataset
uspto-grants-1999_12
Patent number
US06002002

Reaction notes

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