p-Toluenesulfonic acid → HCID 9793772, compound

HRID 611962Notes

Reaction equation

HRID 611962 reaction equation
[CH3:1][C:2]([CH:4]1[CH2:6][CH2:5]1)=[O:3].[CH:7](OC)(OC)[O:8]C.[C:14]1(C)C=CC(S(O)(=O)=O)=CC=1.C[O-].[Na+]>CO>[CH3:14][O:3][C:2]([CH:4]1[CH2:6][CH2:5]1)([O:8][CH3:7])[CH3:1]

Participants

6

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 9005Trimethyl orthoformateHCID 13004Cyclopropyl methyl ketoneHCID 10942334Sodium Methoxide

Product 1

HCID 9793772HCID 9793772, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 50 g (0.59 mol) of cyclopropyl methyl ketone, 82 g (0.77 mol) of trimethyl orthoformate, 200 ml of methanol and 0.25 g of p-toluenesulfonic acid was stirred at room temperature for 2 hours, and then 0.15 g of sodium methoxide was added. Then, under reduced pressure, the methanol was first distilled off (at about 400 mbar) and, finally (at about 250 mbar), the product (II) as a colorless liquid.

Workup

  1. distillationThen, under reduced pressure, the methanol was first distilled off (at about 400 mbar) and, finally (at about 250 mbar)

Sources & evidence

ORD record
ord-5a75d3c7b9884fd1989eec67c5f71a7d
Source dataset
uspto-grants-1999_12
Patent number
US06002062

Reaction notes

Loading…