Potassium Carbonate → HCID 19595476, compound

HRID 612497Notes

Reaction equation

HRID 612497 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([NH2:5])=[O:4].[CH3:8][O:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:18][CH:19]([CH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)[O:20]C(=O)C(F)(F)F.C([O-])([O-])=O.[K+].[K+]>CO>[F:1][C:2]([F:7])([F:6])[C:3]([NH2:5])=[O:4].[CH3:8][O:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:18][CH:19]([CH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)[OH:20]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 19595468HCID 19595468, compound

Product 1

HCID 19595476HCID 19595476, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4-[2-(2,3-dimethoxyphenyl)-1-(trifluoro acetyloxy)ethyl]piperidine trifluoroacetamide compound (2.3 g, 6.0 mmol), K2CO3 (powdered, 1.0 g 6.6 mmol) and anhydrous methanol (15 ml) was stirred at ambient temperature for 3 h. The reaction was filtered and the filtrate concentrated to 2.3 g of a thick, yellow oil. The oil was triturated with Et2O (a white solid resulted). The solid was filtered, and the filtrate concentrated to afford a thick yellow oil.

Workup

  1. filtrationThe reaction was filtered
  2. concentrationthe filtrate concentrated to 2.3 g of a thick, yellow oil
  3. customThe oil was triturated with Et2O (a white solid
  4. customresulted)
  5. filtrationThe solid was filtered
  6. concentrationthe filtrate concentrated
  7. customto afford a thick yellow oil

Sources & evidence

ORD record
ord-ddeddb892da3470a91c79f37c33842c4
Source dataset
uspto-grants-1999_12
Patent number
US06004982

Reaction notes

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