反应详情

Prepare a stirred mixture of ortho-bromo-phenol (25.951 g, 17.4 mL, 0.15 mole) and potassium carbonate (20.70 g, 0.16 mole) in 175 mL isopropanol at ambient temperature under argon. Slowly add isopropyl iodide (22.2 g, 16.00 mL), heat at reflux and stir the mixture overnight. Cool to ambient temperature then filter, condensing the filtrate on a rotary evaporator. Dissolve the residual oil in diethyl ether (300 mL) and twice extract with 100 mL 50% sodium hyroxide. Separate, wash with brine and concentrate on a rotary evaporator to give a pale yellow liquid. Distill on the Kugelrohr (0.05 mm, 100°-120° C.) to obtain the title compound as an oil. (24.21 g, 75%).

1. customPrepare
2. temperatureat reflux
3. filtrationthen filter
4. customcondensing the filtrate
5. customon a rotary evaporator
6. dissolutionDissolve the residual oil in diethyl ether (300 mL)
7. extractiontwice extract with 100 mL 50% sodium hyroxide
8. customSeparate
9. washwash with brine
10. concentrationconcentrate on a rotary evaporator
11. customto give a pale yellow liquid
12. distillationDistill on the Kugelrohr (0.05 mm, 100°-120° C.)