Hydroxyamine hydrochloride → HCID 178518997, compound

HRID 612964Notes

Reaction equation

HRID 612964 reaction equation
C[O:2][C:3](=O)[CH:4]([C:8](=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH:5]1[CH2:7][CH2:6]1.Cl.[NH2:18]O.C[O-].[Na+]>>[CH:5]1([C:4]2[C:3]([OH:2])=[N:18][O:15][C:8]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:7][CH2:6]1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 10942334Sodium MethoxideHCID 11557587HCID 11557587, compound

Product 1

HCID 178518997HCID 178518997, compoundYield 39%

Procedure

2-Benzoyl-2-cyclopropylacetic acid methyl ester (0.9 g), hydroxylamine hydrochloride (0.6 g) and sodium methoxide (28% methanol solution, 4.0 ml) were subjected to reaction and post-treatment in a similar manner to that described in Reference example 8(b) to obtain the title compound (0.32 g, 39%) as colorless crystals.

Sources & evidence

ORD record
ord-522ba5938b954c5d8de4ffc80ac8332e
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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